diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index a968327d..edc56ce6 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -35,7 +35,6 @@ jobs:
           python-version: 3.8
       - name: Install dependencies
         run: |
-          pip install -r requirements.txt
           pip install -r requirements-dev.txt
           pip install tox
       - name: Run tests and collect coverage
@@ -105,7 +104,6 @@ jobs:
     - name: Install dependencies and build
       run: |
         python -m pip install --upgrade pip
-        pip install -r requirements.txt
         pip install setuptools wheel twine
         python setup.py sdist bdist_wheel
     - name: Publish distribution 📦 to PyPI
diff --git a/.gitignore b/.gitignore
index d4a006db..2f7aff65 100644
--- a/.gitignore
+++ b/.gitignore
@@ -9,6 +9,7 @@ htmlcov/
 dist/
 /build/
 *.egg-info/
+.eggs/
 .idea/
 *.swp
 *~
diff --git a/Dockerfile b/Dockerfile
index ce87be2a..10f5dce5 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -13,10 +13,7 @@ RUN python -m venv /opt/venv
 # Make sure we use the virtualenv:
 ENV PATH="/opt/venv/bin:$PATH"
 
-COPY requirements.txt /
-
-RUN pip install --upgrade pip && \
-	pip install -r requirements.txt
+RUN pip install --upgrade pip
 
 WORKDIR /app
 
diff --git a/README.md b/README.md
index b3389be8..a9239778 100644
--- a/README.md
+++ b/README.md
@@ -71,9 +71,8 @@ pip install squeaknode
 Or install from source
 
 ```
-virtualenv venv
+python3 -m venv venv
 source venv/bin/activate
-pip install -r requirements.txt
 pip install .
 ```
 
diff --git a/docs/database-migration.md b/docs/database-migration.md
index 66ef2052..104fc50a 100644
--- a/docs/database-migration.md
+++ b/docs/database-migration.md
@@ -15,9 +15,8 @@ To change any database model, follow these steps.
 	```
 - Run the command to generate a new alembic migration:
 	```
-	virtualenv venv
+	python3 -m venv venv
 	source venv/bin/activate
-	pip install -r requirements.txt
 	pip install -e .
 	alembic -c squeaknode/db/alembic.ini revision --autogenerate -m "<YOUR_MESSAGE>"
 	```
diff --git a/docs/development.md b/docs/development.md
index c868b5d7..0fb82ba9 100644
--- a/docs/development.md
+++ b/docs/development.md
@@ -27,9 +27,8 @@ You can also run your own squeaknode on your host machine.
 
 - Install squeaknode:
 	```
-	virtualenv venv
+	python3 -m venv venv
 	source venv/bin/activate
-	pip install -r requirements.txt
 	pip install .
 	```
 
diff --git a/frontend/README.md b/frontend/README.md
index a40e5323..c242bdec 100755
--- a/frontend/README.md
+++ b/frontend/README.md
@@ -9,9 +9,8 @@
 	```
 - Start the backend with the `SQUEAKNODE_WEBADMIN_ENABLED`, `SQUEAKNODE_WEBADMIN_LOGIN_DISABLED`, and `SQUEAKNODE_WEBADMIN_ALLOW_CORS` environment variables:
 	```
-	virtualenv venv
+	python3 -m venv venv
 	source venv/bin/activate
-	pip install -r requirements.txt
 	pip install .
 	SQUEAKNODE_WEBADMIN_ENABLED=TRUE SQUEAKNODE_WEBADMIN_LOGIN_DISABLED=TRUE SQUEAKNODE_WEBADMIN_ALLOW_CORS=TRUE SQUEAKNODE_NETWORK=testnet squeaknode --config config.ini
 	```
diff --git a/requirements.txt b/requirements.txt
index 9f3c6d74..f791a15f 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -4,8 +4,6 @@ flask-cors==3.0.10
 flask-login==0.5.0
 Flask-WTF==0.15.1
 googleapis-common-protos==1.53.0
-grpcio==1.39.0
-grpcio-tools==1.39.0
 importlib_resources==1.4.0
 mypy-protobuf==2.9
 protobuf==3.17.3
diff --git a/setup.py b/setup.py
index 7dba46e5..daed3de5 100644
--- a/setup.py
+++ b/setup.py
@@ -27,7 +27,6 @@ from typing import Tuple
 import pkg_resources
 import setuptools.command.build_py
 import setuptools.command.test
-from grpc_tools import protoc
 from setuptools import Command
 from setuptools import find_packages
 from setuptools import setup
@@ -48,6 +47,9 @@ class BuildPyCommand(setuptools.command.build_py.build_py):
 
 
 def build_package_protos(package_root, strict_mode=False):
+    # Import grpc_tools here because it is not available at top of module.
+    from grpc_tools import protoc
+
     proto_files = []
     inclusion_root = os.path.abspath(package_root)
     for root, _, files in os.walk(inclusion_root):
@@ -100,6 +102,7 @@ setup(
     packages=find_packages(),
     include_package_data=True,
     zip_safe=False,
+    setup_requires=['grpcio-tools==1.39.0', 'wheel==0.37.1'],
     install_requires=requirements,
     extras_require={
         "test": ["pytest", "coverage"],