diff --git a/src/bitcoin-cli.cpp b/src/bitcoin-cli.cpp
index 86995d6cf8..4b50a763bf 100644
--- a/src/bitcoin-cli.cpp
+++ b/src/bitcoin-cli.cpp
@@ -87,10 +87,10 @@ static void SetupCliArgs(ArgsManager& argsman)
                              "arguments are number of blocks to generate (default: %s) and maximum iterations to try (default: %s), equivalent to "
                              "RPC generatetoaddress nblocks and maxtries arguments. Example: bitcoin-cli -generate 4 1000",
                              DEFAULT_NBLOCKS, DEFAULT_MAX_TRIES),
-                   ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
-    argsman.AddArg("-addrinfo", "Get the number of addresses known to the node, per network and total, after filtering for quality and recency. The total number of addresses known to the node may be higher.", ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
-    argsman.AddArg("-getinfo", "Get general information from the remote server. Note that unlike server-side RPC calls, the output of -getinfo is the result of multiple non-atomic requests. Some entries in the output may represent results from different states (e.g. wallet balance may be as of a different block from the chain state reported)", ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
-    argsman.AddArg("-netinfo", "Get network peer connection information from the remote server. An optional integer argument from 0 to 4 can be passed for different peers listings (default: 0). Pass \"help\" for detailed help documentation.", ArgsManager::ALLOW_ANY, OptionsCategory::OPTIONS);
+                   ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
+    argsman.AddArg("-addrinfo", "Get the number of addresses known to the node, per network and total, after filtering for quality and recency. The total number of addresses known to the node may be higher.", ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
+    argsman.AddArg("-getinfo", "Get general information from the remote server. Note that unlike server-side RPC calls, the output of -getinfo is the result of multiple non-atomic requests. Some entries in the output may represent results from different states (e.g. wallet balance may be as of a different block from the chain state reported)", ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
+    argsman.AddArg("-netinfo", "Get network peer connection information from the remote server. An optional integer argument from 0 to 4 can be passed for different peers listings (default: 0). Pass \"help\" for detailed help documentation.", ArgsManager::ALLOW_ANY, OptionsCategory::CLI_COMMANDS);
 
     SetupChainParamsBaseOptions(argsman);
     argsman.AddArg("-color=<when>", strprintf("Color setting for CLI output (default: %s). Valid values: always, auto (add color codes when standard output is connected to a terminal and OS is not WIN32), never.", DEFAULT_COLOR_SETTING), ArgsManager::ALLOW_ANY | ArgsManager::DISALLOW_NEGATION, OptionsCategory::OPTIONS);
@@ -1221,6 +1221,7 @@ static int CommandLineRPC(int argc, char *argv[])
                 fputc('\n', stdout);
             }
         }
+        gArgs.CheckMultipleCLIArgs();
         std::unique_ptr<BaseRequestHandler> rh;
         std::string method;
         if (gArgs.IsArgSet("-getinfo")) {
diff --git a/src/common/args.cpp b/src/common/args.cpp
index 1fa6e11165..47488db411 100644
--- a/src/common/args.cpp
+++ b/src/common/args.cpp
@@ -20,6 +20,7 @@
 #include <util/fs.h>
 #include <util/fs_helpers.h>
 #include <util/strencodings.h>
+#include <util/string.h>
 
 #ifdef WIN32
 #include <codecvt>    /* for codecvt_utf8_utf16 */
@@ -579,6 +580,23 @@ void ArgsManager::AddHiddenArgs(const std::vector<std::string>& names)
     }
 }
 
+void ArgsManager::CheckMultipleCLIArgs() const
+{
+    LOCK(cs_args);
+    std::vector<std::string> found{};
+    auto cmds = m_available_args.find(OptionsCategory::CLI_COMMANDS);
+    if (cmds != m_available_args.end()) {
+        for (const auto& [cmd, argspec] : cmds->second) {
+            if (IsArgSet(cmd)) {
+                found.push_back(cmd);
+            }
+        }
+        if (found.size() > 1) {
+            throw std::runtime_error(strprintf("Only one of %s may be specified.", util::Join(found, ", ")));
+        }
+    }
+}
+
 std::string ArgsManager::GetHelpMessage() const
 {
     const bool show_debug = GetBoolArg("-help-debug", false);
@@ -629,6 +647,9 @@ std::string ArgsManager::GetHelpMessage() const
             case OptionsCategory::REGISTER_COMMANDS:
                 usage += HelpMessageGroup("Register Commands:");
                 break;
+            case OptionsCategory::CLI_COMMANDS:
+                usage += HelpMessageGroup("CLI Commands:");
+                break;
             default:
                 break;
         }
diff --git a/src/common/args.h b/src/common/args.h
index 381d0ba71b..05bff4a4b9 100644
--- a/src/common/args.h
+++ b/src/common/args.h
@@ -65,6 +65,7 @@ enum class OptionsCategory {
     ELEMENTS,
     COMMANDS,
     REGISTER_COMMANDS,
+    CLI_COMMANDS,
 
     HIDDEN // Always the last option to avoid printing these in the help
 };
@@ -360,6 +361,13 @@ protected:
         m_network_only_args.clear();
     }
 
+    /**
+     * Check CLI command args
+     *
+     * @throws std::runtime_error when multiple CLI_COMMAND arguments are specified
+     */
+    void CheckMultipleCLIArgs() const;
+
     /**
      * Get the help string
      */
diff --git a/src/test/fuzz/system.cpp b/src/test/fuzz/system.cpp
index fecad748bd..e588c888e5 100644
--- a/src/test/fuzz/system.cpp
+++ b/src/test/fuzz/system.cpp
@@ -53,7 +53,7 @@ FUZZ_TARGET(system, .init = initialize_system)
                 args_manager.SoftSetBoolArg(fuzzed_data_provider.ConsumeRandomLengthString(16), fuzzed_data_provider.ConsumeBool());
             },
             [&] {
-                const OptionsCategory options_category = fuzzed_data_provider.PickValueInArray<OptionsCategory>({OptionsCategory::OPTIONS, OptionsCategory::CONNECTION, OptionsCategory::WALLET, OptionsCategory::WALLET_DEBUG_TEST, OptionsCategory::ZMQ, OptionsCategory::DEBUG_TEST, OptionsCategory::CHAINPARAMS, OptionsCategory::NODE_RELAY, OptionsCategory::BLOCK_CREATION, OptionsCategory::RPC, OptionsCategory::GUI, OptionsCategory::COMMANDS, OptionsCategory::REGISTER_COMMANDS, OptionsCategory::HIDDEN});
+                const OptionsCategory options_category = fuzzed_data_provider.PickValueInArray<OptionsCategory>({OptionsCategory::OPTIONS, OptionsCategory::CONNECTION, OptionsCategory::WALLET, OptionsCategory::WALLET_DEBUG_TEST, OptionsCategory::ZMQ, OptionsCategory::DEBUG_TEST, OptionsCategory::CHAINPARAMS, OptionsCategory::NODE_RELAY, OptionsCategory::BLOCK_CREATION, OptionsCategory::RPC, OptionsCategory::GUI, OptionsCategory::COMMANDS, OptionsCategory::REGISTER_COMMANDS, OptionsCategory::CLI_COMMANDS, OptionsCategory::HIDDEN});
                 // Avoid hitting:
                 // common/args.cpp:563: void ArgsManager::AddArg(const std::string &, const std::string &, unsigned int, const OptionsCategory &): Assertion `ret.second' failed.
                 const std::string argument_name = GetArgumentName(fuzzed_data_provider.ConsumeRandomLengthString(16));
diff --git a/test/functional/interface_bitcoin_cli.py b/test/functional/interface_bitcoin_cli.py
index 4ce4afc518..2ffb80c1aa 100755
--- a/test/functional/interface_bitcoin_cli.py
+++ b/test/functional/interface_bitcoin_cli.py
@@ -387,6 +387,9 @@ class TestBitcoinCli(BitcoinTestFramework):
         assert_raises_process_error(1, "Could not connect to the server", self.nodes[0].cli('-rpcwait', '-rpcwaittimeout=5').echo)
         assert_greater_than_or_equal(time.time(), start_time + 5)
 
+        self.log.info("Test that only one of -addrinfo, -generate, -getinfo, -netinfo may be specified at a time")
+        assert_raises_process_error(1, "Only one of -getinfo, -netinfo may be specified", self.nodes[0].cli('-getinfo', '-netinfo').send_cli)
+
 
 if __name__ == '__main__':
     TestBitcoinCli(__file__).main()